A recent UK study looking at genetic-predispositions for producing elevated testosterone levels has apparently confirmed the view that the higher incidence of heart disease and blood clots in men is at least partially accounted for by the hormone (https://www.theguardian.com/society/2019/mar/06/testosterone-linked-to-higher-risk-of-heart-disease-research-finds). They suggest that statins (commonly prescribed to counter elevated cholesterol levels in mature men to reduce their risk of cardiovascular disease) also lower testosterone levels and that men taking testosterone supplements might be putting themselves at risk. Naturally, one could reduce such risk by castration but, I suspect, that would not prove a popular 'remedy'.
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