This blog may help people explore some of the 'hidden' issues involved in certain media treatments of environmental and scientific issues. Using personal digital images, it's also intended to emphasise seasonal (and other) changes in natural history of the Swansea (South Wales) area. The material should help participants in field-based modules and people generally interested in the natural world. The views are wholly those of the author.
Monday 16 November 2020
Perhaps I Have Had a Nocebo Effect?
Like many (some 8 million) 'mature' males in the UK I was prescribed statins by my doctor, to reduce my risk of cardiovascular disease (these compounds reduce circulating cholesterol levels that can cause arteriosclerosis). As around 20% of people, I stopped taking them, when I became convinced I was having side-effects, including fatigue, muscle aches and joint pain. At the time, I found it difficult to run or to push a wheelchair (a neccessary care duty at that time). A study by Imperial College London, convinced 60 patients to go back on to statins (https://www.theguardian.com/society/2020/nov/15/nocebo-effect-cause-of-most-statin-side-effects-research-suggests). They gave them bottles containing statins, an identical-looking placebo or nothing (empty). The 'medications' were taken in a randomly-prescribed order over a year and 'symptoms recorded. The trial found that 90% of the side-effects, were experienced when patients took the placebo. It is concluded that there is a nocebo effect, when someone expects a negative consequence of taking this medication. It is certainly possible that that is what I experienced. I, however, changed my diet, reducing a butter/cream obsession and cutting down on meats. My runs are slow but I manage about 8, pain-free kilometres each day. I prefer this solution and think it's working.
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