Sunday, 29 January 2023

Leaf Scald to the Rescue?

The development of antibiotic-resistant bacteria, risks medicine being rapidly returned to a pre-antibiotic era, where even slight wounds/operations could result in death. There are now, however, big hopes for a new range of bacteriocidal compounds derived from albicidin (https://www.theguardian.com/society/2023/jan/29/plant-toxin-new-weapon-antibiotic-war-against-bacteria-albicidin). Albicidin is a toxin produced by the bacterial plant pathogen, Xanthomonas albineans. Xanthomonas albineans infects Sugar cane, producing a condition called 'Leaf scald'.Albicidin not only attacks the tissues of the Sugar cane (a grass) but is highly effective in killing other bacteria. Recent research, published in Nature Catalysis, suggests that the bacteriocidal mechanism in albicidin would not cause problems in the human body. It's also of interest that, the scientists carrying out that study, were unable to find any evidence that bacteria could become albicidin-resistant. There is consequently the possibility of generating an entirely new range of antibacterial drugs from albicidin. This finding also strongly suggests that more organisms producing antimicrobial agents are 'out there'. Medical advances (like that of Penicillin itself) are sometimes found in the most surprising niches of Biological investigation. We should never ignore so-called 'pure research'.

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