This blog may help people explore some of the 'hidden' issues involved in certain media treatments of environmental and scientific issues. Using personal digital images, it's also intended to emphasise seasonal (and other) changes in natural history of the Swansea (South Wales) area. The material should help participants in field-based modules and people generally interested in the natural world. The views are wholly those of the author.
Saturday, 4 February 2023
Kisspeptin and Make Up?
Kisspeptin-54 (alias Metastin) is a protein that binds, in the brain and elsewhere, to a site called the 'G-protein coupled receptor' (GPR54). This peptide (and its variants) were originally of interest as they suppressed melanoma and breast cancers. Kisspeptin also plays an important role, however, in stimulating gonadotropin-releasing hormone (GRH). GRH is another short peptide, produced in the brain's hypothalamic region. GRH passes via a blood link to the anterior pituitary gland. Here, it stimulates the release of Luteinising Hormone (LH) and Follicle Cell Stimulating Hormone (FSH). LH and FSH control the production of sex steroids (e.g. androgens and oestrogens), regulating sexual maturation and interest. Injections of Kisspeptin consequently appear to alleviate low sexual drive (libido) in both male and female humans (https://www.theguardian.com/society/2023/feb/03/hormone-shots-treatment-low-sex-drive-kisspeptin). Kisspeptin's influence on human sexual behaviour, seems to open a potential goldmine for its manufacturers. Something rather similar happened with Viagra (Sildenafil). Sildenafil was originally developed as a treatment for hypertension (high blood pressure). It's ability to reduce erectile dysfunction in males, was initially seen as a side-effect. Once being identified as 'cures' for human sexual dysfunction, sales of compounds rocket and their names become more 'sexy'! It will be interesting to see whether athletes are allowed to legally use it?
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1 comment:
What about male athletes (of the non-sexual variety)? Kisspeptin stimulates testosterone but this would be from the individual's own endocrine system.
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