Covid19 'Boosters' May Not Boost Everyone?

Effective vaccines for Covid19 were developed with impressive and unexpected speed. These treatments have reduced hospitalisations and deaths from Sars-CoV-2 infections. Danny Altmann (Imperial College London), however, casts doubt on relying too much on vaccine 'boosters' to enable us to 'live' with the virus (https://www.theguardian.com/commentisfree/2022/mar/28/uk-cant-rely-on-boosters-new-wave-covid). Sars-CoV-2 appears to have been much more prone to mutation than other coronaviruses. It has developed many variants, some with the ability to create new 'waves' of infection. The typical response to each wave, in well-vaccinated areas of the globe, has been to give booster doses (some countries are already on their fourth) to enhance 'fading' immune responses. Altmann points to a phenomenon labelled Immune imprinting. Immunity can be developed by infection with the virus and/or treatment with diverse vaccines (including the 'new' mRNA variety). It seems that combinations of exposures to the viral antigens can result in variable immune memory repertoires in patients. Essentially, they may determine how the immune system responds later. Altmann says we need more research on this phenomenon. He suggests, however, that boosters for Covid19 vaccines could produce less predictable and effective results in the future. Perhaps tweaking vaccination programmes is not the most effective way of living with a virus that continues to surprise?