Putting Cancer Out With the 'Trash'?

Modern cancer drugs generally work by blocking the functions of harmful proteins. The Centre for Protein Degradation, at the Institute of Cancer Research, is, however, concentrating a subtly different approach (https://www.theguardian.com/science/2022/apr/03/new-cancer-treatment-uses-bodys-cellular-waste-disposal-to-flag-harmful-proteins). The body's cells have 'built in' protein degradation systems. The systems, however, only recognise specific proteins. The Centre for Protein Degradation attempt to 'put flags' on proteins, resulting in their disposal by the cell's degradation systems. Naturally, the candidate proteins are those, now recognised, as involved in tumour development. For example, the drug lenalidomide, slows down the development of myeloma (a form of blood cancer). A 'selective oestrogen receptor degrader' helps remove a protein, that is an important driver of breast cancer. This approach seems to have lots of potential scope! It's also much kinder to the patient than traditional chemotherapy.